DNA Damage · 1article

DNA damage is any modification to DNA that affects its sequence or normal function in transcription or replication.

Image depicting structure of the amino acid tyrosine and its increase leading to heart failure.

Elevated amino acid levels diminish the DNA Damage Response and increase the risk of heart failure đŸĢ€

A new study shows that an increase in levels of the amino acid tyrosine in the blood plasma is associated with heart failure. Increased tyrosine levels induced DNA damage in cardiac cells. It also weakened the DNA Damage Response by reducing the activation of ATR, one of the key kinases. A weak DNA Damage Response leads to further accumulation of DNA Damage and cell death that eventually causes heart failure.
April 24, 2023